The province's Department of Health confirmed the province's second and third cases of the H1N1 virus - also known as swine flu - this morning.
According to a news release, two children under the age of five, from the same family have tested positive for the disease.
It is not yet known where the children are from, but they are from a community under Eastern Health's jurisdiction.
On Saturday, a young man from Grand Falls-Windsor was the first to be confirmed as having H1N1.
He has since recovered after being treated at the Central Newfoundland Regional Health Centre.
"With a case confirmed last weekend, we anticipated that other cases would be identified," said Dr. Faith Stratton, the province's chief medical officer of health in the release.
"As indicated previously, this is an evolving situation and we can expect additional cases as we head into the summer and fall," she said.
The World Health Organization declared the H1N1 virus a pandemic last week meaning that it has spread world wide.
Symptoms of the illness include fever, lethargy, lack of appetite and coughing. Some people also report runny nose, sore throat, nausea, vomiting and diarrhea.
People should wash their hands regularly, cover coughs and sneezes and stay at home if they think they are sick to avoid the spread of the virus.
People in the province can contact the provincial Healthline at 1-888-709-2929, or go to the Public Health Agency of Canada's website for more information www.phac-aspc.gc.ca
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